Ontology highlight
ABSTRACT:
SUBMITTER: Beerman I
PROVIDER: S-EPMC2851806 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Beerman Isabel I Bhattacharya Deepta D Zandi Sasan S Sigvardsson Mikael M Weissman Irving L IL Bryder David D Rossi Derrick J DJ
Proceedings of the National Academy of Sciences of the United States of America 20100318 12
Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to reduce the regenerative capacity of aged HSCs. Such mechanisms do not however account for the change in lymphoid and myeloid lineage potential characteristic of HSC aging, which is believed to be centra ...[more]