Ontology highlight
ABSTRACT:
SUBMITTER: Myeni SK
PROVIDER: S-EPMC2859494 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20100308 18
Salmonella enterica serovar Typhimurium invade non-phagocytic cells by injecting bacterial effector proteins to exploit the host actin cytoskeleton network. SipC is such a Salmonella effector known to nucleate actin, bundle F-actin, and translocate type III effectors. The molecular mechanism of how SipC bundles F-actin and SipC domains responsible for these activities are not well characterized. We successfully separated these activities through a series of genetic deletion/insertions in SipC. W ...[more]