Ontology highlight
ABSTRACT:
SUBMITTER: Malagelada C
PROVIDER: S-EPMC2880868 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Malagelada Cristina C Jin Zong Hao ZH Jackson-Lewis Vernice V Przedborski Serge S Greene Lloyd A LA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100101 3
We report that rapamycin, an allosteric inhibitor of certain but not all actions of the key cellular kinase mammalian target of rapamycin (mTOR), protects neurons from death in both cellular and animal toxin models of Parkinson's disease (PD). This protective action appears to be attributable to blocked translation of RTP801/REDD1/Ddit4, a protein that is induced in cell and animal models of PD and in affected neurons of PD patients and that causes neuron death by leading to dephosphorylation of ...[more]