Ontology highlight
ABSTRACT:
SUBMITTER: Lee WS
PROVIDER: S-EPMC288191 | biostudies-other | 1993 May
REPOSITORIES: biostudies-other
Lee W S WS Wells R G RG Sabbag R V RV Mohandas T K TK Hediger M A MA
The Journal of clinical investigation 19930501 5
We have recently cloned, sequenced, and characterized a rat kidney cDNA (D2) that stimulates cystine as well as dibasic and neutral amino acid transport. In order to evaluate the role of this protein in human inherited diseases such as cystinuria, we have isolated a human D2 clone (D2H) by low stringency screening of a human kidney cDNA library using the radiolabeled D2 insert as a probe. The D2H cDNA is 2284 nucleotides long and encodes a 663 amino acid protein that is 80% identical to the rat ...[more]