Pan-genome analysis provides much higher strain typing resolution than multi-locus sequence typing.
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ABSTRACT:
SUBMITTER: Hall BG
PROVIDER: S-EPMC2889442 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Publications
Pan-genome analysis provides much higher strain typing resolution than multi-locus sequence typing.
Hall Barry G BG Ehrlich Garth D GD Hu Fen Z FZ
Microbiology (Reading, England) 20091217 Pt 4
The most widely used DNA-based method for bacterial strain typing, multi-locus sequence typing (MLST), lacks sufficient resolution to distinguish among many bacterial strains within a species. Here, we show that strain typing based on the presence or absence of distributed genes is able to resolve all completely sequenced genomes of six bacterial species. This was accomplished by the development of a clustering method, neighbour grouping, which is completely consistent with the lower-resolution ...[more]
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