Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.
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ABSTRACT: This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.
SUBMITTER: Williams R
PROVIDER: S-EPMC2889702 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
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