Ontology highlight
ABSTRACT:
SUBMITTER: Bender AM
PROVIDER: S-EPMC6104635 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
ACS chemical neuroscience 20180426 7
The pharmacology of the M<sub>5</sub> muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort around the prototypical M<sub>5</sub> positive allosteric modulator (PAM) ML380 and have discovered and optimized a new series of M<sub>5</sub> PAMs based on a chiral N-(indanyl)piperidine amide core with robust SAR, human and rat M<sub>5</ ...[more]