The Mohawk homeobox gene is a critical regulator of tendon differentiation.
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ABSTRACT:
SUBMITTER: Ito Y
PROVIDER: S-EPMC2890854 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Publications
The Mohawk homeobox gene is a critical regulator of tendon differentiation.
Ito Yoshiaki Y Toriuchi Naoya N Yoshitaka Teruhito T Ueno-Kudoh Hiroe H Sato Tempei T Yokoyama Shigetoshi S Nishida Keiichiro K Akimoto Takayuki T Takahashi Michiko M Miyaki Shigeru S Asahara Hiroshi H
Proceedings of the National Academy of Sciences of the United States of America 20100524 23
Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx ...[more]
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