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Hydrodynamic trap for single particles and cells.


ABSTRACT: Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 mum) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 mum of the trap center, corresponding to a trap stiffness of approximately 10(-5)-10(-4) pNnm.

SUBMITTER: Tanyeri M 

PROVIDER: S-EPMC2892531 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

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