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Inhibition of HIV fusion with multivalent gold nanoparticles.

ABSTRACT: The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.

SUBMITTER: Bowman MC

PROVIDER: S-EPMC2916654 | biostudies-other | 2008 Jun

REPOSITORIES: biostudies-other

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Inhibition of HIV fusion with multivalent gold nanoparticles.

Bowman Mary-Catherine MC Ballard T Eric TE Ackerson Christopher J CJ Feldheim Daniel L DL Margolis David M DM Melander Christian C

Journal of the American Chemical Society 20080513 22

The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs ...[more]

PMID: 18473457

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