Ontology highlight
ABSTRACT:
SUBMITTER: Yavari A
PROVIDER: S-EPMC2945252 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Developmental cell 20100701 1
The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generation of PI4P, exhibits hh loss-of-function phenotypes, whereas loss of Sac1 phosphatase, which is required for the degradation of PI4P, results in hh gain-of-function phenotypes in mul ...[more]