Ontology highlight
ABSTRACT:
SUBMITTER: Garmaroudi FS
PROVIDER: S-EPMC2947887 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Garmaroudi Farshid S FS Marchant David D Si Xiaoning X Khalili Abbas A Bashashati Ali A Wong Brian W BW Tabet Aline A Ng Raymond T RT Murphy Kevin K Luo Honglin H Janes Kevin A KA McManus Bruce M BM
Proceedings of the National Academy of Sciences of the United States of America 20100910 39
Signal transduction networks can be perturbed biochemically, genetically, and pharmacologically to unravel their functions. But at the systems level, it is not clear how such perturbations are best implemented to extract molecular mechanisms that underlie network function. Here, we combined pairwise perturbations with multiparameter phosphorylation measurements to reveal causal mechanisms within the signaling network response of cardiomyocytes to coxsackievirus B3 (CVB3) infection. Using all pos ...[more]