(1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydr-oxy-5-phenyl-4-(picolinamido)pent-yl]carbamate.

ABSTRACT: The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydr-oxy-5-phenyl-pent-yl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two mol-ecules in the asymmetric unit, which are aligned edge-to-face. In one mol-ecule, the pyridyl ring forms a dihedral angle of 22.0?(1)° with the phenyl ring of the terminal benzyl group and 14.3?(1)° with the other phenyl ring; in the other mol-ecule, the corresponding angles are 12.1?(1) and 10.6?(1)°, respectively. The packing is stabilized by inter-molecular hydrogen bonds and C-H?? inter-actions.

SUBMITTER: Zheng JF 

PROVIDER: S-EPMC2961835 | biostudies-other | 2008

REPOSITORIES: biostudies-other