Ontology highlight
ABSTRACT:
SUBMITTER: Louis CU
PROVIDER: S-EPMC2964409 | biostudies-other | 2010 Nov-Dec
REPOSITORIES: biostudies-other
Louis Chrystal U CU Straathof Karin K Bollard Catherine M CM Ennamuri Sravya S Gerken Claudia C Lopez Teresita T TT Huls M Helen MH Sheehan Andrea A Wu Meng-Fen MF Liu Hao H Gee Adrian A Brenner Malcolm K MK Rooney Cliona M CM Heslop Helen E HE Gottschalk Stephen S
Journal of immunotherapy (Hagerstown, Md. : 1997) 20101101 9
Patients with recurrent or refractory Epstein Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) continue to have poor outcomes. Our earlier Phase I dose escalation clinical study of 10 NPC patients showed that infusion of EBV-specific cytotoxic T cells (EBV-CTLs) was safe and had antitumor activity. To better define the overall response rate and discover whether disease status, EBV-antigen specificity, and/or in vivo expansion of infused EBV-CTLs predicted outcome, we treated 13 additiona ...[more]