Ontology highlight
ABSTRACT:
SUBMITTER: Ho L
PROVIDER: S-EPMC297615 | biostudies-other | 1989 Jul
REPOSITORIES: biostudies-other
Ho L L Wexler I D ID Liu T C TC Thekkumkara T J TJ Patel M S MS
Proceedings of the National Academy of Sciences of the United States of America 19890701 14
A cDNA clone (1423 base pairs) comprising the entire coding region of the precursor form of the alpha subunit of pyruvate dehydrogenase (E1 alpha) has been isolated from a human liver cDNA library in phage lambda gt11. The first 29 amino acids deduced from the open reading frame correspond to a typical mitochondrial targeting leader sequence. The remaining 361 amino acids, starting at the N terminus with phenylalanine, represent the mature mitochondrial E1 alpha peptide. The cDNA has 43 base pai ...[more]