Ontology highlight
ABSTRACT:
SUBMITTER: Schneuwly S
PROVIDER: S-EPMC297628 | biostudies-other | 1989 Jul
REPOSITORIES: biostudies-other
Schneuwly S S Shortridge R D RD Larrivee D C DC Ono T T Ozaki M M Pak W L WL
Proceedings of the National Academy of Sciences of the United States of America 19890701 14
Mutations in the ninaA gene of Drosophila severely reduce the amount of rhodopsin specifically in R1-6 photoreceptors. Isolation of the ninaA gene by chromosomal walking revealed that it is expressed only in the eye and encodes a 237-amino acid polypeptide that shows strong sequence similarity to cyclophilin, a putative molecular target for cyclosporine A, a potent immunosuppressant used in human organ transplantations. Unlike most cyclophilins characterized to date, the ninaA-encoded protein ha ...[more]