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(1R,3S,5R,6S)-6-Hydr-oxy-3-tosyl-oxy-tropan-8-ium chloride.

ABSTRACT: The title compound, C(15)H(22)NO(4)S(+)·Cl(-), is a hydrolysis product of lesatropane [(1R,3S,5R,6S)-6-acet-oxy-3-tosyl-oxytropane] hydro-chloride, a potential anti-glaucoma agent. As in lesatropane, the piperidine and pyrrolidine rings in the title compound adopt chair and envelope conformations, respectively. There are two mol-ecules in the unit cell with similar conformations. The crystal structure is stabilized by inter-molecular O-H?Cl and N-H?Cl hydrogen bonds.

SUBMITTER: Yu NX

PROVIDER: S-EPMC2979886 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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(1R,3S,5R,6S)-6-Hydr-oxy-3-tosyl-oxy-tropan-8-ium chloride.

Yu Nian-Xi NX Yang Li-Min LM Lu Yang Y

Acta crystallographica. Section E, Structure reports online 20100109 Pt 2

The title compound, C(15)H(22)NO(4)S(+)·Cl(-), is a hydrolysis product of lesatropane [(1R,3S,5R,6S)-6-acet-oxy-3-tosyl-oxytropane] hydro-chloride, a potential anti-glaucoma agent. As in lesatropane, the piperidine and pyrrolidine rings in the title compound adopt chair and envelope conformations, respectively. There are two mol-ecules in the unit cell with similar conformations. The crystal structure is stabilized by inter-molecular O-H⋯Cl and N-H⋯Cl hydrogen bonds. ...[more]

PMID: 21579747

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