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(1R,3aR,5aS,6S,8aR,8bR,9aS)-1-Hydr-oxy-6-isopropyl-1,3a,5a-trimethyl-perhydro-cyclo-penta-[a]cyclo-propa[i]naphthalen-4-one.

ABSTRACT: The title compound (also know as azorellanone), C(20)H(32)O(2), is built up from three fused carbocycles, one five-membered ring and two six-membered rings. The five membered-ring has an envelope conformation, whereas the six-membered rings have a distorted half-chair and a twist-boat conformation. In the crystal, mol-ecules are linked by O-H?O inter-actions into zigzag chains with graph-set notation C(8) along [010]. The absolute configuration was assigned on the basis of earlier chemical studies.

SUBMITTER: Brito I

PROVIDER: S-EPMC2979771 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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(1R,3aR,5aS,6S,8aR,8bR,9aS)-1-Hydr-oxy-6-isopropyl-1,3a,5a-trimethyl-perhydro-cyclo-penta-[a]cyclo-propa[i]naphthalen-4-one.

Brito Iván I Bórquez Jorge J Loyola Luis Alberto LA Bolte Michael M Albanez Joselyn J

Acta crystallographica. Section E, Structure reports online 20100116 Pt 2

The title compound (also know as azorellanone), C(20)H(32)O(2), is built up from three fused carbocycles, one five-membered ring and two six-membered rings. The five membered-ring has an envelope conformation, whereas the six-membered rings have a distorted half-chair and a twist-boat conformation. In the crystal, mol-ecules are linked by O-H⋯O inter-actions into zigzag chains with graph-set notation C(8) along [010]. The absolute configuration was assigned on the basis of earlier chemical studi ...[more]

PMID: 21579782

Similar Datasets

Crystal structure of rac-(3aR,4S,5aR,6S,9R,10aS,10bR)-3a,5a,9-tri-methyl-tetra-deca-hydro-6,9-ep-oxy-cyclo-hepta-[e]inden-4-ol monohydrate.

Project description:The title hydrate, C17H28O2·H2O, was synthesized in order to determine the relative configuration of the tetra-cyclic framework. The fused 5,6,7-tricarbocyclic core exhibits an entire cis-annulation, featuring a 1,4-cis-relation of the angular methyl groups in the six-membered ring. The oxa bridge of the ep-oxy-cyclo-heptane moiety is oriented towards the concave face of the boat-shaped mol-ecule, whereas the angular methyl groups are directed towards the convex face. The asymmetric unit of the crystal contains two nearly identical formula units, which are related via a pseudo-centre of symmetry. The structure could be solved in the space groups I-4 and I41/a. The refinement in the acentric space group, however, gave significantly better results and these are used in this paper. O-H⋯O hydrogen bonds are observed between the organic mol-ecules, between the organic mol-ecules and the water mol-ecules, and between the water mol-ecules, forming a chain along the c-axis direction.

| S-EPMC4555390 | biostudies-literature

(2S,4aR,3S,8aR,9R,10R)-1,4-Diallyl-2,3-diphenyl-perhydro-quinoxaline.

Project description:In the title compound, C(26)H(32)N(2), the cyclo-hexane and piperazine rings each adopt a chair conformation. Both phenyl rings and the two propen-3-yl residues are in equatorial positions. There are no C-H?N hydrogen bonds nor ?-? inter-actions between the aromatic rings. The absolute configuration was assigned with reference to the starting material.

| S-EPMC2961322 | biostudies-literature

(6S,7S,8R,8aS)-6-Ethyl-perhydro-indolizine-7,8-diol.

Project description:In the title compound, C(10)H(19)NO(2), the piperidine and pyrrolidine rings of the perhydro-indolizine ring system adopt chair and envelope conformations, respectively. In the crystal structure, inter-molecular O-H⋯N and O-H⋯O hydrogen bonds link the mol-ecules into a chain running along the a axis.

| S-EPMC3006912 | biostudies-literature

(3aR,8aR)-2,2,6,6-Tetra-methyl-4,4,8,8-tetra-phenyl-tetra-hydro-1,3-dioxolo[4,5-e][1,3,2]dioxasilepine.

Project description:The title compound, C(33)H(34)O(4)Si, is a dioxasilepine compound, an effective chiral dopant for the determination of high helical twisting powers in liquid crystals. Its structure consists of a five-membered dioxolo ring fused to a seven-membered dioxasilepine ring which contains two sets of phenyl rings in a twisted butterfly shape attached to the two Csp(3) atoms in the ring opposite each other. Two methyl groups are attached to the Si atom in the ring and two additional methyl groups are attached to the Csp(3) atom in the dioxolo ring (one of which is disordered) and which lies in an envelope pattern. The dihedral angles between the mean planes of the phenyl ring pairs are 85.9?(2) and 83.5?(1)°. The dihedral angles between the mean planes of the dioxolo ring and the two pairs of butterfly shaped phenyl rings are 46.2?(1), 67.7?(1), 35.6?(7) and 83.5?(1)°.

| S-EPMC2968053 | biostudies-literature

Ethyl 1'-methyl-2-oxo-4'-[(3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetra-methyl-tetra-hydro-3aH-bis-[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-yl]-2H-spiro-[ace-naphthyl-ene-1,2'-pyrrolidine]-3'-carboxyl-ate.

Project description:In the title mol-ecule, C30H35NO8, the ace-naphthyl-enone moiety, two atoms of a methyl pyrrolidine ring (N and C atoms) and four atoms of an ethyl acetate moiety (two C and two O atoms) are disordered over two sets of sites in ratio 0.532?(7):0.468?(7). The three C atoms of a di-meth-oxy-ethane ring and dioxolane ring attached with two methyl groups are disordered over two sets of sites in 0.66?(2):0.34?(2) and 0.62?(2):0.38?(2) ratios, respectively. The major and minor components of the ace-naphthyl-ene ring are essentially planar (r.m.s. deviations = 0.0254 and 0.0436?Å, respectively). The major and minor components of the pyrrolidine ring adopt C-envelope conformations with C atoms displaced by 0.492?(11) and 0.595?(7)?Å from the remaining ring atoms. One of the dioxolane rings is disordered with its major component in an envelope conformation [C displaced by 0.511?(11)?Å] and the minor fraction is more or less planar with an r.m.s. deviation of 0.070?Å. The other dioxolane ring is in an envelope conformation, with a C atom displaced by 0.438?(3)?Å from the remainder of the ring atoms. The crystal packing features C-H?O inter-actions, which generate C(9) chains.

| S-EPMC3790386 | biostudies-literature

(3aR*,7aS*)-1-(p-Tolyl-sulfon-yl)perhydro-indol-2-one.

Project description:In the racemic title compound, C(15)H(19)NO(3)S, the dihedral angle between the planes of the benzene ring and the O=S=O group is 56.92?(7)° and the cyclo-hexane ring adopts a chair conformation.

| S-EPMC2979223 | biostudies-other

rac-(3aR,6aR)-(E)-Methyl 2-(3a-methyl-perhydro-furo[3,2-b]furan-2-yl-idene)acetate.

Project description:The constitution and relative configuration at the stereogenic centres and stereochemistry of the C-C double bond formed during Pd(II)-catalysed domino reaction was established by X-ray analysis of the title compound, C(10)H(14)O(4). The asymmetric unit contains two mol-ecules.

| S-EPMC3007948 | biostudies-literature

(3aR,8aS,9S,9aR)-9-Hydroxy-perhydro-furo[3,2-f]indolizin-6-one.

Project description:In the title compound, C(10)H(15)NO(3), the central six-membered ring of the indolizine system adopts a chair conformation, while the oxopyrrolidine and hydro-furan rings attached to the indolizine ring system have envelope conformations. In the crystal, the mol-ecules form chains parallel to the b axis via inter-molecular O-H?O hydrogen bonds. The absolute configuration was assigned from the synthesis.

| S-EPMC2977186 | biostudies-other

(3aR,6S,7aR)-7a-Bromo-2-methyl-sulfonyl-1,2,3,6,7,7a-hexa-hydro-3a,6-ep-oxy-isoindole.

Project description:In the title compound, C(9)H(12)BrNO(3)S, the two tetra-hydro-furan rings adopt envelope conformations, the pyrrolidine ring adopts a half-chair conformation and the six-membered ring is in a boat conformation. In the crystal, weak inter-molecular C-H?O hydrogen bonds link the mol-ecules into R(2) (2)(8) and R(2) (2)(14) rings along the b-axis direction.

| S-EPMC3120297 | biostudies-literature

(2R,3R,4aS,6S,7S,8aS)-4a-Fluoro-8a-hy-droxy-perhydro-naphthalene-2,3,6,7-tetrayl tetraacetate.

Project description:The title compound, C(18)H(25)FO(9), exhibits a similar unit cell and packing to the ? polymorph of axial 4a,8a-dihy-droxy-per-hydro-naph-tha-lene-2,3,6,7-tetrayl tetraacetate. The carbonyl O atoms of two of the four acetate groups in the molecule are disordered over two sites with occupancy ratios of 0.59?(4):0.41?(4) and 0.57?(6):0.43?(6). Crystal packing is effected via inter-molecular O-H?O hydrogen bonds, which link the tetra-acetate mol-ecules into tapes along the c axis.

| S-EPMC3011589 | biostudies-literature

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