Ontology highlight
ABSTRACT:
SUBMITTER: Lubahn DB
PROVIDER: S-EPMC298531 | biostudies-other | 1989 Dec
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19891201 23
Androgens act through a receptor protein (AR) to mediate sex differentiation and development of the male phenotype. We have isolated the eight exons in the amino acid coding region of the AR gene from a human X chromosome library. Nucleotide sequences of the AR gene intron/exon boundaries were determined for use in designing synthetic oligonucleotide primers to bracket coding exons for amplification by the polymerase chain reaction. Genomic DNA was amplified from 46,XY phenotypic female siblings ...[more]