Ontology highlight
ABSTRACT:
SUBMITTER: Mierzwa A
PROVIDER: S-EPMC3001347 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101101 47
We have used fluorescent dextran tracers to test the tightness of the paranodal junction of living or fixed myelinated fibers in mouse sciatic nerve. Both 3 and 70 kDa tracers are able to penetrate from the perinodal space symmetrically into the paranodes on either side of the node of Ranvier at a rate consistent with diffusion through an elongated helical pathway between the paranodal terminal loops of the myelin sheath. This pathway thus provides an access route for movement of water soluble n ...[more]