Enantioselective synthesis of (-)-sclerophytin A by a stereoconvergent epoxide hydrolysis.
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ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC3005712 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Publications
Enantioselective synthesis of (-)-sclerophytin A by a stereoconvergent epoxide hydrolysis.
Wang Bin B Ramirez Armando P AP Slade Justin J JJ Morken James P JP
Journal of the American Chemical Society 20101028 46
The cytotoxic natural product (-)-sclerophytin A was constructed in 13 steps from geranial. Highlights from the synthesis are a stereoselective Oshima-Utimoto reaction, a Shibata-Baba indium-promoted radical cyclization, and a novel stereoconvergent epoxide hydrolysis. ...[more]
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