Ontology highlight
ABSTRACT:
SUBMITTER: Yamaji S
PROVIDER: S-EPMC3009836 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Yamaji Sachie S Zhang Mingjun M Zhang Jing J Endo Yoko Y Bibikova Elena E Goff Stephen P SP Cang Yong Y
Proceedings of the National Academy of Sciences of the United States of America 20101206 51
Etiologic risk factors for hepatocellular carcinoma can be involved in the transformation process by directly targeting intracellular signaling pathways or by indirectly stimulating chronic cycles of hepatocyte destruction and regeneration. However, the contribution of these two routes to hepatocarcinogenesis has not been determined, partly because of the difficulty in distinguishing damaged and regenerated hepatocytes. Here we report that induced deletion of the damaged DNA binding protein 1 (D ...[more]