Ontology highlight
ABSTRACT:
SUBMITTER: Hildebrand JD
PROVIDER: S-EPMC301225 | biostudies-other | 1995 Jun
REPOSITORIES: biostudies-other
Hildebrand J D JD Schaller M D MD Parsons J T JT
Molecular biology of the cell 19950601 6
Focal adhesion kinase (pp125FAK or FAK) and paxillin colocalize with integrins in structures called focal adhesions. pp125FAK plays an important role in the transmission of integrin-induced cytoplasmic signals. Paxillin has also been implicated in cell signaling by virtue of its association with the protein tyrosine kinases pp60src and Csk (C-terminal Src kinase) as well as with the adapter/oncoprotein p47gag-crk. In this report we show that endogenous pp125FAK and paxillin form a stable complex ...[more]