Ontology highlight
ABSTRACT:
SUBMITTER: Tokarev AA
PROVIDER: S-EPMC3014196 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Journal of virology 20101027 1
The HIV-1 protein Vpu counteracts the antiviral activity of the innate restriction factor BST-2/tetherin by a mechanism that partly depends on its interaction with β-TrCP, a substrate adaptor for an SCF (Skp-Cullin 1-F box) E3 ubiquitin ligase complex. This suggests that Vpu stimulates the ubiquitination of BST-2 and that this underlies the relief of restriction. Here, we show that Vpu stimulates ubiquitination of BST-2. Mutation of all potential ubiquitination sites in the cytoplasmic domain of ...[more]