Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3024803 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Chen Li L Romero Lizbeth L Chuang Show-Mei SM Tournier Vincent V Joshi Kishore Kumar KK Lee Jung Ah JA Kovvali Gopala G Madura Kiran K
The Journal of biological chemistry 20101112 4
The evidence that nuclear proteins can be degraded by cytosolic proteasomes has received considerable experimental support. However, the presence of proteasome subunits in the nucleus also suggests that protein degradation could occur within this organelle. We determined that Sts1 can target proteasomes to the nucleus and facilitate the degradation of a nuclear protein. Specific sts1 mutants showed reduced nuclear proteasomes at the nonpermissive temperature. In contrast, high expression of Sts1 ...[more]