Ontology highlight
ABSTRACT:
SUBMITTER: Metzler KD
PROVIDER: S-EPMC3035083 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Metzler Kathleen D KD Fuchs Tobias A TA Nauseef William M WM Reumaux Dominique D Roesler Joachim J Schulze Ilka I Wahn Volker V Papayannopoulos Venizelos V Zychlinsky Arturo A
Blood 20101025 3
The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable. Serious microbial infections, especially with Candida species, have been observed in a subset of completely MPO-deficient patients. Here we show that neutrophils from donors who are completely deficient in MPO fail to form neutrophil extracellular traps (NETs), indicating that MPO is required for NET f ...[more]