Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
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ABSTRACT:
SUBMITTER: Martin-Orozco N
PROVIDER: S-EPMC3058814 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Publications
Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
Martin-Orozco Natalia N Li Yufeng Y Wang Yijun Y Liu Shijuan S Hwu Patrick P Liu Yong-Jun YJ Dong Chen C Radvanyi Laszlo L
Cancer research 20101123 23
CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion ...[more]
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