Ontology highlight
ABSTRACT:
SUBMITTER: Ma HH
PROVIDER: S-EPMC3061826 | biostudies-other | 2011
REPOSITORIES: biostudies-other
Ma Hui-Hui HH Ziegler Judy J Li Cuiling C Sepulveda Antonia A Bedeir Ahmed A Grandis Jennifer J Lentzsch Suzanne S Mapara Markus Y MY
Cellular immunology 20110204 1
The aim of this study was to delineate the temporal and spatial sequence of STAT1 and STAT3 activation during development of GVHD following fully Major Histocompatibility Complex (MHC)-mismatched allogeneic Bone Marrow Transplantation (BMT). Activation of inflammatory signaling pathways in GVHD target organs was assessed by western blotting, phospho-flow cytometry and electromobility shift assays (EMSA). Development of GVHD was associated with significant expansion of phospho[p]-STAT1 and p-STAT ...[more]