Ontology highlight
ABSTRACT:
SUBMITTER: Hartwell MJ
PROVIDER: S-EPMC5291735 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Hartwell Matthew J MJ Özbek Umut U Holler Ernst E Renteria Anne S AS Major-Monfried Hannah H Reddy Pavan P Aziz Mina M Hogan William J WJ Ayuk Francis F Efebera Yvonne A YA Hexner Elizabeth O EO Bunworasate Udomsak U Qayed Muna M Ordemann Rainer R Wölfl Matthias M Mielke Stephan S Pawarode Attaphol A Chen Yi-Bin YB Devine Steven S Harris Andrew C AC Jagasia Madan M Kitko Carrie L CL Litzow Mark R MR Kröger Nicolaus N Locatelli Franco F Morales George G Nakamura Ryotaro R Reshef Ran R Rösler Wolf W Weber Daniela D Wudhikarn Kitsada K Yanik Gregory A GA Levine John E JE Ferrara James Lm JL
JCI insight 20170209 3
<b>BACKGROUND.</b> No laboratory test can predict the risk of nonrelapse mortality (NRM) or severe graft-versus-host disease (GVHD) after hematopoietic cellular transplantation (HCT) prior to the onset of GVHD symptoms. <b>METHODS.</b> Patient blood samples on day 7 after HCT were obtained from a multicenter set of 1,287 patients, and 620 samples were assigned to a training set. We measured the concentrations of 4 GVHD biomarkers (ST2, REG3α, TNFR1, and IL-2Rα) and used them to model 6-month NRM ...[more]