Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC3064225 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Hu Xin X Kim Jin Ah JA Castillo Andy A Huang Michael M Liu Jianxin J Wang Bin B
The Journal of biological chemistry 20110131 13
BRCC36-deubiquitinating enzyme (DUB) forms two different complexes through interactions with two different adaptor proteins Abraxas and ABRO1 in cells. Abraxas mainly localizes in the nucleus, mediating the interaction of BRCC36 with BRCA1. ABRO1 is mainly localized in the cytoplasm. Because it lacks the BRCA1-interacting motif, the ABRO1 complex does not interact with BRCA1. Both BRCC36-containing complexes contain common components including BRE and NBA1/MERIT40. Here, we found that the two co ...[more]