Ontology highlight
ABSTRACT:
SUBMITTER: Cremona ML
PROVIDER: S-EPMC3066276 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Cremona M Laura ML Matthies Heinrich J G HJ Pau Kelvin K Bowton Erica E Speed Nicole N Lute Brandon J BJ Anderson Monique M Sen Namita N Robertson Sabrina D SD Vaughan Roxanne A RA Rothman James E JE Galli Aurelio A Javitch Jonathan A JA Yamamoto Ai A
Nature neuroscience 20110313 4
Plasmalemmal neurotransmitter transporters (NTTs) regulate the level of neurotransmitters, such as dopamine (DA) and glutamate, after their release at brain synapses. Stimuli including protein kinase C (PKC) activation can lead to the internalization of some NTTs and a reduction in neurotransmitter clearance capacity. We found that the protein Flotillin-1 (Flot1), also known as Reggie-2, was required for PKC-regulated internalization of members of two different NTT families, the DA transporter ( ...[more]