Ontology highlight
ABSTRACT:
SUBMITTER: Papanicolaou KN
PROVIDER: S-EPMC3067905 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Papanicolaou Kyriakos N KN Khairallah Ramzi J RJ Ngoh Gladys A GA Chikando Aristide A Luptak Ivan I O'Shea Karen M KM Riley Dushon D DD Lugus Jesse J JJ Colucci Wilson S WS Lederer W Jonathan WJ Stanley William C WC Walsh Kenneth K
Molecular and cellular biology 20110118 6
Mitofusin-2 (Mfn-2) is a dynamin-like protein that is involved in the rearrangement of the outer mitochondrial membrane. Research using various experimental systems has shown that Mfn-2 is a mediator of mitochondrial fusion, an evolutionarily conserved process responsible for the surveillance of mitochondrial homeostasis. Here, we find that cardiac myocyte mitochondria lacking Mfn-2 are pleiomorphic and have the propensity to become enlarged. Consistent with an underlying mild mitochondrial dysf ...[more]