Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC307737 | biostudies-other | 1994 Jan
REPOSITORIES: biostudies-other
Kumar S S Cheng X X Klimasauskas S S Mi S S Posfai J J Roberts R J RJ Wilson G G GG
Nucleic acids research 19940101 1
The m5C-MTases form a closely-knit family of enzymes in which common amino acid sequence motifs almost certainly translate into common structural and functional elements. These common elements are located predominantly in a single structural domain that performs the chemistry of the reaction. Sequence-specific DNA recognition is accomplished by a separate domain that contains recognition elements not seen in other structures. This, combined with the novel and unexpected mechanistic feature of tr ...[more]