Ontology highlight
ABSTRACT:
SUBMITTER: Germain AR
PROVIDER: S-EPMC3086581 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
The Journal of organic chemistry 20110314 8
Enantioselective syntheses of the azaphilone natural products (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine that possess the natural R-configuration at the quaternary center are reported. The syntheses were accomplished using copper-mediated asymmetric dearomatization employing bis-μ-oxo copper complexes prepared from readily available (+)-sparteine surrogates. Of note, site-selective O-methylation of a vinylogous pyridone was used to access the isoquinolin-6(7H)-one core of (+)-8-O-methy ...[more]