Ontology highlight
ABSTRACT:
SUBMITTER: Giorgianni MW
PROVIDER: S-EPMC3087180 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Giorgianni Matt W MW Mann Richard S RS
Developmental cell 20110401 4
The proximodistal (PD) axis of the Drosophila leg is thought to be established by the combined gradients of two secreted morphogens, Wingless (Wg) and Decapentaplegic (Dpp). According to this model, high [Wg+Dpp] activates Distalless (Dll) and represses dachshund (dac) in the distal cells of the leg disc, while intermediate [Wg+Dpp] activates dac in medial tissue. To test this model we identified and characterized a dac cis-regulatory element (dac RE) that recapitulates dac's medial expression d ...[more]