Ontology highlight
ABSTRACT:
SUBMITTER: Dong A
PROVIDER: S-EPMC3093902 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20110326 20
Anterior Gradient Homolog 2 (AGR2) is expressed by the normal intestine and by most human adenocarcinomas, including those derived from the esophagus, pancreas, lung, breast, ovary, and prostate. Xenografts of human adenocarcinoma cell lines in nude mice previously demonstrated that AGR2 supports tumor growth. In addition, AGR2 is able to induce in vitro a transformed phenotype in fibroblast and epithelial cell lines. The mechanism underlying the growth promoting effects of AGR2 is unknown. The ...[more]