Ontology highlight
ABSTRACT:
SUBMITTER: Taverna S
PROVIDER: S-EPMC5466625 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Taverna Simona S Pucci Marzia M Giallombardo Marco M Di Bella Maria Antonietta MA Santarpia Mariacarmela M Reclusa Pablo P Gil-Bazo Ignacio I Rolfo Christian C Rolfo Christian C Alessandro Riccardo R
Scientific reports 20170609 1
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing osteoclasts and bone-forming osteoblasts activity is lost in bone metastasis, inducing osteoclastogenesis. In NSCLC, the epidermal growth factor receptor (EGFR) pathway is constitutively activated. EGFR ...[more]