Macrocyclic chelator assembled RGD multimers for tumor targeting.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3098922 | biostudies-other | 2011 Jun
REPOSITORIES: biostudies-other
Publications
Macrocyclic chelator assembled RGD multimers for tumor targeting.
Zhang Xiaofen X Liu Hongguang H Miao Zheng Z Kimura Richard R Fan Feiyue F Cheng Zhen Z
Bioorganic & medicinal chemistry letters 20110405 11
Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability. ...[more]
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