Evolutionary variation of the CCAAT-binding transcription factor NF-Y.
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ABSTRACT:
SUBMITTER: Li XY
PROVIDER: S-EPMC312095 | biostudies-other | 1992 Mar
REPOSITORIES: biostudies-other
Publications
Evolutionary variation of the CCAAT-binding transcription factor NF-Y.
Li X Y XY Mantovani R R Hooft van Huijsduijnen R R Andre I I Benoist C C Mathis D D
Nucleic acids research 19920301 5
NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subun ...[more]
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