Ontology highlight
ABSTRACT:
SUBMITTER: Trang P
PROVIDER: S-EPMC3129804 | biostudies-other | 2011 Jun
REPOSITORIES: biostudies-other
Trang Phong P Wiggins Jason F JF Daige Christopher L CL Cho Chris C Omotola Michael M Brown David D Weidhaas Joanne B JB Bader Andreas G AG Slack Frank J FJ
Molecular therapy : the journal of the American Society of Gene Therapy 20110322 6
MicroRNAs (miRNAs) are emerging as potential cancer therapeutics, but effective delivery mechanisms to tumor sites are a roadblock to utility. Here we show that systemically delivered, synthetic miRNA mimics in complex with a novel neutral lipid emulsion are preferentially targeted to lung tumors and show therapeutic benefit in mouse models of lung cancer. Therapeutic delivery was demonstrated using mimics of the tumor suppressors, microRNA-34a (miR-34a) and let-7, both of which are often down r ...[more]