Ontology highlight
ABSTRACT:
SUBMITTER: Croci L
PROVIDER: S-EPMC3131878 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Croci L L Barili V V Chia D D Massimino L L van Vugt R R Masserdotti G G Longhi R R Rotwein P P Consalez G G GG
Cell death and differentiation 20100702 1
IGF1, an anabolic and neuroprotective factor, promotes neuronal survival by blocking apoptosis. It is released into the bloodstream by the liver, or synthesized locally by muscles and neural cells, acting in an autocrine or paracrine fashion. Intriguingly, genetic studies conducted in invertebrate and murine models also suggest that an excess of IGF1 signaling may trigger neurodegeneration. This emphasizes the importance of gaining a better understanding of the mechanisms controlling IGF1 regula ...[more]