Ontology highlight
ABSTRACT:
SUBMITTER: Rowe RG
PROVIDER: S-EPMC3133420 | biostudies-other | 2011 Jun
REPOSITORIES: biostudies-other
Rowe R Grant RG Lin Yongshun Y Shimizu-Hirota Ryoko R Hanada Shinichiro S Neilson Eric G EG Greenson Joel K JK Weiss Stephen J SJ
Molecular and cellular biology 20110411 12
Chronic exposure of the liver to hepatotoxic agents initiates an aberrant wound healing response marked by proinflammatory, as well as fibrotic, changes, leading to compromised organ structure and function. In a variety of pathological states, correlative links have been established between tissue fibrosis and the expression of transcription factors associated with the induction of epithelial-mesenchymal cell transition (EMT) programs similar to those engaged during development. However, the rol ...[more]