Unknown

Dataset Information

0

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

ABSTRACT: Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290-295(-/-) mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure.

SUBMITTER: Medeiros LA 

PROVIDER: S-EPMC3161528 | biostudies-other | 2011 Aug

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

Medeiros Lea A LA   Dennis Lucas M LM   Gill Mark E ME   Houbaviy Hristo H   Markoulaki Styliani S   Fu Dongdong D   White Amy C AC   Kirak Oktay O   Sharp Phillip A PA   Page David C DC   Jaenisch Rudolf R  

Proceedings of the National Academy of Sciences of the United States of America 20110815 34

Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating pri  ...[more]

Similar Datasets

Unknown Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.
| S-EPMC4237010 | biostudies-literature
Unknown Complete antithrombin deficiency in mice results in embryonic lethality.
| S-EPMC517819 | biostudies-literature
Unknown Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
| S-EPMC3630102 | biostudies-literature
Unknown Ubiquitous expression of Akt1 p.(E17K) results in vascular defects and embryonic lethality in mice.
| S-EPMC7871364 | biostudies-literature
Unknown Autotaxin overexpression causes embryonic lethality and vascular defects.
| S-EPMC4438000 | biostudies-literature
Unknown Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
| S-EPMC7803460 | biostudies-literature
Unknown Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice.
| S-EPMC2767504 | biostudies-literature
Unknown Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells.
| S-EPMC6770266 | biostudies-literature
Unknown MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.
| S-EPMC4939759 | biostudies-literature
Unknown Embryonic lethality and defective male germ cell development in mice lacking UTF1.
| S-EPMC5722945 | biostudies-literature