Ontology highlight
ABSTRACT:
SUBMITTER: Graham B
PROVIDER: S-EPMC4939759 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Stem cell reports 20160414 5
Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regulate bivalent genes and the bivalent state remain incompletely understood. Examining the contribution of microRNAs (miRNAs) to the regulation of bivalent genes, we found that the miRNA biogenesis enzyme ...[more]