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Radiative transport-based frequency-domain fluorescence tomography.

ABSTRACT: We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs.

SUBMITTER: Joshi A

PROVIDER: S-EPMC3166518 | biostudies-other | 2008 Apr

REPOSITORIES: biostudies-other

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Radiative transport-based frequency-domain fluorescence tomography.

Joshi Amit A Rasmussen John C JC Sevick-Muraca Eva M EM Wareing Todd A TA McGhee John J

Physics in medicine and biology 20080326 8

We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport sol ...[more]

PMID: 18364555

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