Ontology highlight
ABSTRACT:
SUBMITTER: Johnston DM
PROVIDER: S-EPMC3190167 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Johnston Danika M DM Sedkov Yurii Y Petruk Svetlana S Riley Kristen M KM Fujioka Miki M Jaynes James B JB Mazo Alexander A
Molecular cell 20111001 1
The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or repress gene transcription depending on the presence or absence, respectively, of the hormone ecdysone. Unexpectedly, we found an alternative mechanism at work in salivary glands during the ecdysone-dependent transition from larvae to pupae. In the absense of ecdysone, both ecdysone receptor subunits localize to the cytoplasm, and the heme-binding nuclear receptor E75A replaces EcR/Usp at common target sequences in several gene ...[more]