Ontology highlight
ABSTRACT:
SUBMITTER: Spratley SJ
PROVIDER: S-EPMC3190831 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20110809 39
Dynamic reorganization of the actin cytoskeleton at the leading edge is required for directed cell migration. Cofilin, a small actin-binding protein with F-actin severing activities, is a key enzyme initiating such actin remodeling processes. Cofilin activity is tightly regulated by phosphorylation and dephosphorylation events that are mediated by LIM kinase (LIMK) and the phosphatase slingshot (SSH), respectively. Protein kinase D (PKD) is a serine/threonine kinase that inhibits actin-driven di ...[more]