Ontology highlight
ABSTRACT:
SUBMITTER: Chen VP
PROVIDER: S-EPMC3190869 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Chen Vicky P VP Choi Roy C Y RC Chan Wallace K B WK Leung K Wing KW Guo Ava J Y AJ Chan Gallant K L GK Luk Wilson K W WK Tsim Karl W K KW
The Journal of biological chemistry 20110727 38
Acetylcholinesterase (AChE) anchors onto cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric form in vertebrate brain. The assembly of AChE tetramer with PRiMA requires the C-terminal "t-peptide" in AChE catalytic subunit (AChE(T)). Although mature AChE is well known N-glycosylated, the role of glycosylation in forming the physiologically active PRiMA-linked AChE tetramer has not been studied. Here, several lines of evidence indicate that the N-linked g ...[more]