Ontology highlight
ABSTRACT:
SUBMITTER: Rozgaja TA
PROVIDER: S-EPMC3192301 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Rozgaja Tania A TA Grimwade Julia E JE Iqbal Maryam M Czerwonka Christopher C Vora Mansi M Leonard Alan C AC
Molecular microbiology 20110914 2
The onset of chromosomal DNA replication requires highly precise and reproducible interactions between initiator proteins and replication origins to assemble a pre-replicative complex (pre-RC) that unwinds the DNA duplex. In bacteria, initiator protein DnaA, bound to specific high- and low-affinity recognition sites within the unique oriC locus, comprises the pre-RC, but how complex assembly is choreographed to ensure precise initiation timing during the cell cycle is not well understood. In thi ...[more]