Ontology highlight
ABSTRACT:
SUBMITTER: He P
PROVIDER: S-EPMC3192861 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
He Peijian P Lee Sei-Jung SJ Lin Songbai S Seidler Ursula U Lang Florian F Fejes-Toth Geza G Naray-Fejes-Toth Aniko A Yun C Chris CC
Molecular biology of the cell 20110824 20
Na(+)/H(+) exchanger 3 (NHE3) is the major Na(+) transporter in the intestine. Serum- and glucocorticoid-induced kinase (SGK) 1 interacts with NHE regulatory factor 2 (NHERF2) and mediates activation of NHE3 by dexamethasone (Dex) in cultured epithelial cells. In this study, we compared short-term regulation of NHE3 by Dex in SGK1-null and NHERF2-null mice. In comparison to wild-type mice, loss of SGK1 or NHERF2 significantly attenuated regulation of NHE3 by Dex but did not completely obliterate ...[more]